Quad Marker Maternal Serum Screening with Dimeric Inhibin-A

Sunrise Medical Laboratories is pleased to announce the availability of Quad Marker Maternal Serum Screening.  

• The Quad Marker detection rate represents an increase of 7-12% over triple marker testing and 10-22% over double marker protocols.^1-4
• Quad Marker screening utilizes AFP, hCG, uE3 and dimeric inhibin-A (DIA) to assess risk for open neural tube defects, Down syndrome, and trisomy 18.
• The Quad Marker detection rate for Down syndrome is about 78-80% overall, and 85-90% for women 35 and older.  

Predicted Down Syndrome Screening Performance
for a Second Trimester Risk Cutoff of 1 in 290 (risk of 35 year old woman)¹

*Biparietal diameter (BPD)

• Detection rates remain at 75% for open neural tube defects and 60-80% for trisomy 18

  Your Prenatal Screening Resource 

• Patient informational brochures on Maternal Serum Screening are available to assist your staff in explaining the benefits and limitations of these maternal serum-screening options.
• Best possible risk estimates are achieved by attention to each case and adjustment for patients’ gestational age, weight, race/ethnicity, diabetic status, and family history.

• An experienced Laboratory Director is available to answer questions about prenatal screening or individual cases.

¹  Haddow et al. J Med Screen 1998;5:115-9. 
²   Wald et al.  Prenat Diagn 1996;16:143-53. 
³  Aitken et al.   N Eng J Med 1996;334:1231-6. 
⁴  Cuckle et al.   Prenat Diagn 1996;16:1101-10. 

RESULT RECALCULATION – When you need it!

If the gestational age changes by 10 days or more, our staff is available to immediately recalculate screening results and fax a Revised Report.  This helps to minimize patient anxiety whenever possible, and to avoid unnecessary, invasive and costly follow-up procedures.

PRENATAL SCREENING PROGRAM INFORMATION

• Quad Marker Testing is offered between 15.0 and 21.9 weeks of gestation (optimal time is between 16 and 18 weeks)
• Patient information required to most accurately report Quad Marker results includes:

• For best screening performance, providing information on pregnancy dating by ultrasound is strongly recommended, when available.
• Open neural tube defect and Down syndrome risk assessment are available for twin pregnancies using Quad Marker testing.
• The sample is separated serum (2 mL minimum), or SST or red-top clot tube.  Do not freeze.  
• Hemolyzed samples cannot be accepted for Quad Marker testing and MUST be redrawn.
• All Screen Positive results are called and faxed.
• Insurance Coverage for this test is just like any other laboratory test

           Sunrise Test #: 3999      Sample Requirement: Serum       Turn-around time: 3-4 days 

For more information, contact us.